The authors describe the factors affecting reconstitution time of dry powder for injection and classifies them as intrinsic and extrinsic parameters.
Jul 2, 2008
By:Pradip Hiwale, Aeshna Amin, Lokesh Kumar, Arvind K. Bansal
The authors describe the factors affecting reconstitution time of dry powder for injection and classifies them as intrinsic and extrinsic parameters.
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The selection of an appropriate salt form for a potential drug candidate is an opportunity to modulate its characteristics to improve bioavailability, stability, manufacturability, and patient compliance.
Mar 2, 2008
By:Lokesh Kumar, Aeshna Amin, Arvind K. Bansal
The selection of an appropriate salt form for a potential drug candidate is an opportunity to modulate its characteristics to improve bioavailability, stability, manufacturability, and patient compliance.
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Oct 2, 2006
By:Aeshna Amin, Arvind K. Bansal
Plastic has emerged gradually as a viable packaging material, even for sterile products. Acceptance of plastics has been encouraged by blow–fill–seal (BFS) technology, which provides scientific and commercial benefits. BFS technology has, however, brought new challenges for formulation-development scientists. This article highlights the specific concerns for the development of sterile liquid products and the formulation strategies to address these concerns.
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The authors propose a decision-tree approach for reverse engineering an innovator tablet formulation to quickly and effectively develop a generic formulation
Aug 2, 2005
By:Arvind K. Bansal, Vishal Koradia
Being the first to gain the most is a fundamental principle in the generics business because several companies compete to create generics of successful products going off patent. For a generics company to maintain revenue growth in a market in which product prices continue to fall, it must secure a continuous flow of new products, with quality and speed to market being key drivers. Thus, generics companies must be highly skilled in product and process development (1), the generics business, and achieving bioequivalence—the most critical development area.
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Jan 2, 2004
By:Arvind K. Bansal
The authors examine the development and performance of coprocessed excipients, including testing them for flowability, compressibility, amd dilution potential.
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Jul 2, 2003
By:Arvind K. Bansal
The bioavailability and absorption of orally administered drugs can be improved by prolonging gastroretention through the use of floating, swelling, bioadhesive, or high-density systems.
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Mar 1, 2002
By:Arvind K. Bansal
The development of a successful powder for injection formulation requires careful study of preformulation parameters, packaging and process parameters, and the elimination of particulate matter.
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