http://pharmtech.findpharma.com/pharmtech A publication providing practical information on pharmaceutical manufacturing. Content focuses on applied R&D technology, process control and computer-integrated manufacturing, biotechnology and technical management. 2010-03-15T21:37:10Z http://pharmtech.findpharma.com/pharmtech/Waters-Accela-Form---NA---Fast-Screening-for-Vitam/ArticleStandard/Article/detail/661310?ref=25 Waters Accela Form - NA - Fast Screening for Vitamins and Dyes in Health Beverages with the ACQUITY UPLC H-Class System 2010-03-15T04:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/122010/661310null HTML http://pharmtech.findpharma.com/pharmtech/Waters-Accela-Form---Europe---Fast-Screening-for-V/ArticleStandard/Article/detail/661311?ref=25 Waters Accela Form - Europe - Fast Screening for Vitamins and Dyes in Health Beverages with the ACQUITY UPLC H-Class System 2010-03-15T04:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/122010/661311null HTML http://pharmtech.findpharma.com/pharmtech/Analytics/Implementing-PAT-and-QbD-Real-time-particle-size-m/ArticleStandard/Article/detail/661193?ref=25 As the pharmaceutical industry implements PAT and QbD, their symbiotic nature becomes increasingly obvious. Both are catalysts towards the longer term goals of continuous operation and real-time release - the realization of a transformed way of working. This article reviews changing practice within the pharmaceutical industry using the example of real-time particle size analysis to explore the analytical solutions needed and the benefits they deliver. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/661193null REMOTE http://pharmtech.findpharma.com/pharmtech/Manufacturing/Maximize-Tablet-Press-Productivity/ArticleStandard/Article/detail/661185?ref=25 Tabletting: Increasing Output and Decreasing Downtime without the need for Conventional Dies. Unique Segmented Turret Assembly Demonstrates Real-World Results In Pharmaceutical Manufacturing. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/661185null REMOTE http://pharmtech.findpharma.com/pharmtech/Manufacturing/Computer-modelling-the-freeze-drying-process/ArticleStandard/Article/detail/659512?ref=25 Despite numerous benefits, computer modelling has mainly remained in the domain of academic research. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659512null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Vacuum-Hsmallsub2subsmallOsmallsub2subsmall-gas-st/ArticleStandard/Article/detail/659514?ref=25 Lyophiliser sterilisation is a common demand of the pharmaceutical industry. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659514null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Cleaning-freeze-dryers/ArticleStandard/Article/detail/659251?ref=25 Freeze dryer internal surfaces become contaminated, post cycle, by the ablation of API and excipient from the freeze?drying cake. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659251null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Freeze-drying-of-biologicals/ArticleStandard/Article/detail/659473?ref=25 When freeze drying biological materials, the major concern is achieving product consistency both within a batch and between batches. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659473null HTML http://pharmtech.findpharma.com/pharmtech/Malvern-Accela-Form---Implementing-PAT-and-QbD--re/ArticleStandard/Article/detail/661136?ref=25 Malvern Accela Form - Implementing PAT and QbD ? real-time particle size measurement for the pharmaceutical industry 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/661136null HTML http://pharmtech.findpharma.com/pharmtech/Pharmaceutical-safety-programme-launched/ArticleStandard/Article/detail/660562?ref=25 A UK consortium has completed pilot runs of a pharmaceutical safety programme that uses electronic tracking and authentication to ensure the safety of drugs in the supply chain. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660562null HTML http://pharmtech.findpharma.com/pharmtech/News/Rheumatoid-arthritis-treatment-suspended/ArticleStandard/Article/detail/660561?ref=25 Following a number of serious adverse events, including infections and fatalities, Roche and Biogen Idec have suspended the late-stage development of Ocrelizumab for the treatment of rheumatoid arthritis (RA). 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660561null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Selecting-a-freeze-dryer/ArticleStandard/Article/detail/659474?ref=25 The most important consideration when choosing a freeze dryer is to ensure the system is fit for both today's applications and future needs. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659474/OctoPlus_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659474null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Engineering-trends-and-developments-in-lyophilizat/ArticleStandard/Article/detail/659472?ref=25 Lyophilization is an expensive process that demands high investments in technology, but for many products, pharmaceutical freeze drying is currently the only method to ensure durability. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659472null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Measuring-headspace-gas-concentrations-and-residua/ArticleStandard/Article/detail/659249?ref=25 Technological advances and regulatory documents, such as Annex 1 of the EU Guideline for Good Manufacturing Practice, have encouraged the pharmaceutical industry to install various new technologies into their production lines. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659249null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Developing-a-safe-lyophilised-adjuvant-vaccine/ArticleStandard/Article/detail/660343?ref=25 There are a variety of vaccine types, each varying in safety and efficacy, and each possessing its own formulation challenges. To overcome potential instabilities when developing vaccines, one formulation strategy is to produce a dried product. 2010-03-12T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660343null HTML http://pharmtech.findpharma.com/pharmtech/Filling-Now-for-the-Future/ArticleStandard/Article/detail/660962?ref=25 Recent developments demonstrate the importance of biologicals, which usually are delivered through injections, for the drug industry?s future. To find out about the process of manufacturing prefilled syringes, and to learn about innovations in filling lines, Equipment and Processing Report talked to Thomas Otto, managing director of Vetter. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660962null HTML http://pharmtech.findpharma.com/pharmtech/Analytics/Week-Of-March-8-2010-Company-And-People-Notes-Exel/ArticleStandard/Article/detail/660623?ref=25 Exelixis And XenoPort Announce Job Cuts; GSK Dedicates India Facility; And More. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660623null HTML http://pharmtech.findpharma.com/pharmtech/March-2010-Editors-Picks-Products-from-Munters-and/ArticleStandard/Article/detail/660967?ref=25 PharmTech's monthly newsletter, Equipment and Processing Report, reviews the Editor's Picks for the March 2010 edition from Munters and NETZSCH. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660967null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/FDA-Issues-Guidance-for-Manufacturing-Cell-Based-V/ArticleStandard/Article/detail/660637?ref=25 The US Food and Drug Administration recently published guidance for the characterization and qualification of cell substrates, viral seeds, and other biological materials used to manufacture viral vaccines for human use. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660637null HTML http://pharmtech.findpharma.com/pharmtech/FETTE-Accela-Form---Maximize-Tablet-Press-Producti/ArticleStandard/Article/detail/660987?ref=25 FETTE Accela Form - Maximize Tablet Press Productivity 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660987null HTML http://pharmtech.findpharma.com/pharmtech/Camfil-Farr-APC-Accela-Form---ASKING-THE-RIGHT-QUE/ArticleStandard/Article/detail/660992?ref=25 Camfil Farr APC Accela Form - ASKING THE RIGHT QUESTIONS ABOUT CARTRIDGE DUST COLLECTION 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660992null HTML http://pharmtech.findpharma.com/pharmtech/Regulation/Regulatory-Roundup-FDA-Published-The-International/ArticleStandard/Article/detail/660635?ref=25 FDA Published The International Conference on Harmonization S9 Guideline; ISPE Released A New Good Practice Guide On Manufacturing Execution Systems. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660635null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/WHO-Releases-New-Malaria-Treatment-and-Drug-Procur/ArticleStandard/Article/detail/660634?ref=25 The World Health Organization released new guidelines this week for the treatment of malaria and the first-ever guidelines on procuring safe and efficacious antimalarial drugs. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660634null HTML http://pharmtech.findpharma.com/pharmtech/The-Continuous-Quest-for-Process-Improvement/ArticleStandard/Article/detail/660961?ref=25 Continuous manufacturing could bring the pharmaceutical industry advantages such as improved product quality, easy scale-up, flexibility, and short cycle times. But how can a company switch from batch to continuous manufacturing? 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660961null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Pharmaceutical-Safety-Program-Launched/ArticleStandard/Article/detail/660630?ref=25 A UK consortium completed pilot runs of a pharmaceutical-safety program that uses electronic tracking and authentication to ensure the safety of drugs in the supply chain. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660630null HTML http://pharmtech.findpharma.com/pharmtech/Regulation/PhRMA-Seeks-Policy-Changes-to-Proposed-Russian-Pha/ArticleStandard/Article/detail/660674?ref=25 The Pharmaceutical Research and Manufacturers of America, along with eight other pharmaceutical, business, and trade organizations, are calling on Russian authorities to consider policy changes concerning clinical-trial regulation and intellectual property. 2010-03-11T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660674null HTML http://pharmtech.findpharma.com/pharmtech/Interphex-2010-Exhibitor-Booth-Invitations/ArticleStandard/Article/detail/659516?ref=25 Interphex 2010 Exhibitor Booth Invitations. You are invited to visit the following company booths at Interphex 2010, Apr. 20-22, in New York City. 2010-03-10T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659516null HTML http://pharmtech.findpharma.com/pharmtech/EtQ-Accela-Form---Managing-Your-Risk-Has-Its-Rewar/ArticleStandard/Article/detail/660659?ref=25 EtQ Accela Form - Managing Your Risk Has Its Rewards: No Nasty Surprises, for Instance 2010-03-09T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660659null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Managing-Your-Risk-Has-Its-Rewards-No-Nasty-Surpri/ArticleStandard/Article/detail/660679?ref=25 In this paper, we will examine a real-world example of how using a risk assessment model in a quality management system can identify critical adverse events, mitigate the risk, and prevent re-occurrence of these events. 2010-03-09T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660679null REMOTE http://pharmtech.findpharma.com/pharmtech/Big-Pharma-faces-major-slow-down/ArticleStandard/Article/detail/659732?ref=25 Top pharmaceutical and biotech companies will witness a major slow down in sales growth between 2008 and 2014, according to business analysts Datamonitor. 2010-03-05T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659732null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Merck-KGaA-Agrees-to-Buy-Millipore-for-72-Billion/ArticleStandard/Article/detail/659634?ref=25 Merck KGaA has agreed to acquire Millipore for EUR 5.3 billion ($7.2 billion). 2010-03-04T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659634null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/FDA-and-EMA-Allow-Single-Annual-Report-for-Orphan-/ArticleStandard/Article/detail/659608?ref=25 The US Food and Drug Administration and the European Medicines Agency are implementing a streamlined process to help regulators better identify and share information regarding orphan-drug and biologic products. 2010-03-04T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659608null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/FDA-and-NIH-Collaborate-to-Speed-the-Introduction-/ArticleStandard/Article/detail/659615?ref=25 Last week, the US Food and Drug Administration and the National Institutes of Health unveiled plans to establish a Joint Leadership Council to address important public-health issues. 2010-03-04T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659615null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Big-Pharma-Faces-Major-Slowdown/ArticleStandard/Article/detail/659605?ref=25 Top pharmaceutical and biotech companies should expect a major slowdown in sales growth between 2008 and 2014, according to business analysts Datamonitor. 2010-03-04T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659605null HTML http://pharmtech.findpharma.com/pharmtech/Analytics/Week-Of-March-1-2010-Company-And-People-Notes-Aste/ArticleStandard/Article/detail/659603?ref=25 Astellas Pharma Makes Bid for OSI Pharmaceuticals; Ringo Retiring From Pfizer; And More. 2010-03-04T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659603null HTML http://pharmtech.findpharma.com/pharmtech/METTLER-TOLEDO-LiquiPhysics153-Excellence-density-/ArticleStandard/Article/detail/659733?ref=25 METTLER TOLEDO?s new LiquiPhysics™ Excellence range of density meters and refractometers offer reliable measurement of density, specific gravity, refractive index and Brix, HFCS, alcohol concentrations and API degrees/gravity. 2010-03-03T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659733null HTML http://pharmtech.findpharma.com/pharmtech/The-Opportunities-Challenges-and-Trends-in-Biomanu/ArticleStandard/Article/detail/659541?ref=25 Nigel Darby, vice-president of biotechnologies at GE Healthcare Life Sciences and speaker at the Drug, Chemical, and Associated Technologies Association (DCAT) upcoming educational program on biologics, offers insight into the current and future state of upstream and downstream processing of biologics. 2010-03-03T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659541null HTML http://pharmtech.findpharma.com/pharmtech/Feature+Articles/Pfizer-Outlines-Postacquisition-Manufacturing-Stra/ArticleStandard/Article/detail/659538?ref=25 Following its $68-billion acquisition of Wyeth, Pfizer is integrating its manufacturing and outsourcing activities (Podcast). 2010-03-03T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659538/pfizer_new_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659538null HTML http://pharmtech.findpharma.com/pharmtech/Outsourcing+Outlook/A-Bio-View-of-Outsourcing/ArticleStandard/Article/detail/659539?ref=25 Strategic rather than tactical considerations are driving biopharmaceutical outsourcing. 2010-03-03T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659539null XML http://pharmtech.findpharma.com/pharmtech/Roundup-of-Informex-2010/ArticleStandard/Article/detail/659542?ref=25 At last month's Informex, exhibitors announced expansions and new partnerships relating to contract manufacturing of active pharmaceuticals and intermediates and fine-chemicals supply. 2010-03-03T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659542null HTML http://pharmtech.findpharma.com/pharmtech/IT/Report-from-India/ArticleStandard/Article/detail/660537?ref=25 Could President Obama's tax reform, which is tareted at reducing outsourcing, endanger India's contract-services industry? 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660537/India-P18_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660537null XML http://pharmtech.findpharma.com/pharmtech/Article/Statistically-Justifiable-Visible-Residue-Limits/ArticleStandard/Article/detail/660526?ref=25 Current methods for establishing visible residue limits (VRLs) are not statistically justifiable. The author proposes a method for estimating VRLs based on logistic regression. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660526null XML http://pharmtech.findpharma.com/pharmtech/IT/Quick-Saves-and-Near-Misses/ArticleStandard/Article/detail/660536?ref=25 From last-minute product inserts to putting out fires, close calls are a common occurrence. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660536null XML http://pharmtech.findpharma.com/pharmtech/Ingredients/Industry-Pipeline/ArticleStandard/Article/detail/660531?ref=25 Pre-Interphex 2010 Product Releases. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660531null XML http://pharmtech.findpharma.com/pharmtech/Industry+Leaders/Baxter-Internationals-Shaun-Newlon-on-Manufacturin/ArticleStandard/Article/detail/661160?ref=25 The vice-president addresses shifts in process and more. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/661160/Pharma-Caps-0310_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/661160null XML http://pharmtech.findpharma.com/pharmtech/Article/Its-Showtime/ArticleStandard/Article/detail/660523?ref=25 Visitors to Interphex will find an abundance of packaging innovations. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660523null XML http://pharmtech.findpharma.com/pharmtech/Ingredients/Spherical-Crystallization-for-Lean-Solid-Dose-Manu/ArticleStandard/Article/detail/660520?ref=25 In Part I of this article, the authors describe the materials and methods used in developing a screening strategy to accelerate the preparation and characterization of spherical agglomerates by spherical crystallization. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660520/Lee-P73_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660520null XML http://pharmtech.findpharma.com/pharmtech/Article/Excipient-Pedigree-as-a-Supply-Chain-Tool/ArticleStandard/Article/detail/660529?ref=25 It's time to maintain a thorough traceable excipient trail. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660529null XML http://pharmtech.findpharma.com/pharmtech/Ingredients+Insider/Navigating-the-Global-Pharmaceutical-Supply-Chain/ArticleStandard/Article/detail/660521?ref=25 Emerging markets remain an important element in the strategies of pharmaceutical companies and their suppliers. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660521null XML http://pharmtech.findpharma.com/pharmtech/IT/Skinny-or-Dead/ArticleStandard/Article/detail/660533?ref=25 If both sides of the aisle don't agree on even mild healthcare reform soon, the bill could die out. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660533null XML http://pharmtech.findpharma.com/pharmtech/IT/Pharma-Capsules/ArticleStandard/Article/detail/660527?ref=25 Brief pharmaceutical news items for March 2010. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660527null XML http://pharmtech.findpharma.com/pharmtech/Ingredients/Uptick-or-Sustainable-Growth/ArticleStandard/Article/detail/660525?ref=25 Contract manufacturers report improving business conditions, but will they continue? 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660525null XML http://pharmtech.findpharma.com/pharmtech/IT/Consumers-Need-Access-to-Lower-Cost-Biogenerics/ArticleStandard/Article/detail/660532?ref=25 To best carry out the vision of Hatch-Waxman, Congress must act now on biogenerics. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660532null XML http://pharmtech.findpharma.com/pharmtech/Outsourcing+Outlook/Time-for-a-Model-Upgrade/ArticleStandard/Article/detail/660522?ref=25 CMOs' business model has all of the flaws of the captive model it is meant to replace. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660522null XML http://pharmtech.findpharma.com/pharmtech/Ingredients/Opportunities-in-the-Biosimilars-Market/ArticleStandard/Article/detail/660530?ref=25 Analysis of the opportunities and challenges in the biosimilars market. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660530/onlineEX_main.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660530null XML http://pharmtech.findpharma.com/pharmtech/IT/In-Search-of-a-Sterile-Fill/ArticleStandard/Article/detail/660524?ref=25 Technological developments make it easier to manufacture sterile parenterals. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660524/CV-P46_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660524null XML http://pharmtech.findpharma.com/pharmtech/Article/Strategic-Sourcing-Focuses-on-Risk-Mitigation/ArticleStandard/Article/detail/660535?ref=25 Pharmaceutical companies and their suppliers share approaches in risk mitigation in sourcing and ways to optimize the outsourced relationship. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660535/onlineEX_main.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660535null XML http://pharmtech.findpharma.com/pharmtech/Regulation/Health-IT-Promises-More-Timely-Drug-Information/ArticleStandard/Article/detail/660534?ref=25 FDA modernizes information systems, expands access to drug safety and use information. 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660534null XML http://pharmtech.findpharma.com/pharmtech/IT/In-the-Spotlight/ArticleStandard/Article/detail/660528?ref=25 Editors' Picks of Pharmaceutical Science & Technology Innovations 2010-03-02T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660528null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Selecting-a-freeze-dryer/ArticleStandard/Article/detail/658092?ref=25 The most important consideration when choosing a freeze dryer is to ensure the system is fit for both today's applications and future needs. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658092/OctoPlus_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658092null XML http://pharmtech.findpharma.com/pharmtech/Focus-on-freeze-drying-digital-supplement/ArticleStandard/Article/detail/661085?ref=25 Our digital magazine takes a close look at the challenges and trends of lyophilisation, as well as some of the latest innovations. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/661085null HTML http://pharmtech.findpharma.com/pharmtech/IT/An-Overview-of-Rapid-Microbial-Detection-Methods/ArticleStandard/Article/detail/660541?ref=25 Pharmaceutical Technology talked to drugmakers, equipment vendors, and service providers to learn more about the advantages and disadvantages of rapid microbial-detection methods. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660541null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Surface-Plasmon-Resonance-as-an-Analytical-Tool-fo/ArticleStandard/Article/detail/660543?ref=25 A Q&A with GE Healthcare 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660543/onlineEX_main.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660543null XML http://pharmtech.findpharma.com/pharmtech/Analytics/The-Myth-Called-Sterility/ArticleStandard/Article/detail/660544?ref=25 The authors propose a process-centric approach for carrying out aseptic-processing and suggest further dialogue. This articles contains bonus online-exclusive material. Part of a new Special Issue on Bioprocessing and Sterile Manufacturing 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660544/MythSterilityP45_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660544/Bonus_main.gif http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660544null XML http://pharmtech.findpharma.com/pharmtech/News/ArticleStandard/Article/detail/658091?ref=25 A round up of some of the news and trends from across the globe. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658091null XML http://pharmtech.findpharma.com/pharmtech/iNexerai-151-the-cleanest-and-fastest-UHPLC-ever-t/ArticleStandard/Article/detail/659213?ref=25 HPLC systems represent the latest development in liquid chromatography instrumentation. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659213null HTML http://pharmtech.findpharma.com/pharmtech/Peer-Reviewed+Research/SMEDDS-incorporated-polymer-matrix-A-floating-dosa/ArticleStandard/Article/detail/658094?ref=25 A new kind of gastro-retentive dosage form for drugs with poor aqueous solubility was developed and evaluated, with the aim of achieving gastro-retention. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658094/Patel_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658094null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Challenges-and-trends-in-lyophilization/ArticleStandard/Article/detail/658093?ref=25 Pharmaceutical Technology Europe discusses some of the latest challenges and innovations in pharmaceutical lyophilization. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658093/OctoPlus_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658093null XML http://pharmtech.findpharma.com/pharmtech/Ingredients/Trends-in-Bioprocessing/ArticleStandard/Article/detail/660539?ref=25 The second annual Pharmaceutical Technology Bioprocessing Survey offers a snapshot of the industry following 2009's megamergers. This articles contains bonus online-exclusive material. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660539/Survey-PS4_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660539/Bonus_main.gif http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660539null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Enhancing-the-bioavailability-of-poorly-soluble-dr/ArticleStandard/Article/detail/659217?ref=25 Although efforts have been made to improve solubility, many poorly soluble drugs still reach the market. Peter Nielsen discusses new developments in solubilisation technology, which could help those companies seeking to reinvigorate marketed products. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659217/ATE_thumb_thumbnail.gif http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659217null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Thermal-fingerprinting-a-way-to-optimise-lyophiliz/ArticleStandard/Article/detail/659469?ref=25 Freeze drying is widely used in pharmaceuticals to improve the long-term storage stability of labile drugs. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659469/OctoPlus_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659469null XML http://pharmtech.findpharma.com/pharmtech/Compliance-Accela-Form---Principals-of-Viral-Clear/ArticleStandard/Article/detail/659341?ref=25 Compliance Accela Form - Principals of Viral Clearance Study Design and Performance 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659341null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Moisture-activated-dry-granulation-The-one-pot-pro/ArticleStandard/Article/detail/658090?ref=25 Moisture-activated drying granulation is a simple and effective process for particle size enlargement. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658090/Wang_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658090null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Reinvigorating-European-RampD-innovation/ArticleStandard/Article/detail/658086?ref=25 Could a collaborative approach involving both public and private parties offer a solution to Europe's lack of innovation? 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658086null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Cost-Advantages-of-Single-Use-Technologies/ArticleStandard/Article/detail/660540?ref=25 Single-use technologies can help simplify equipment and facility design, thus bringing cost advantages. But how are these cost advantages realized and what criteria can be used to assess their impact? 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660540null XML http://pharmtech.findpharma.com/pharmtech/Outsourcing/Disposable-Technologies-for-Fill-Finish-of-Clinica/ArticleStandard/Article/detail/660547?ref=25 The author examines the use and advantages of disposable technologies in the fill–finish of sterile pharmaceutical products and how these technologies can reduce costs and time in producing clinical-trial materials. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660547null XML http://pharmtech.findpharma.com/pharmtech/Analytics/Industrialized-Production-of-Human-iPSC-Derived-Ca/ArticleStandard/Article/detail/660546?ref=25 The authors describe an industrialized process for the manufature of iPSC-derived human cardiomyocytes. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660546/Stem-Cells-Ps8_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660546null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/A-Detail-View-of-Single-Use-Equipment-Opportunitie/ArticleStandard/Article/detail/660545?ref=25 The authors propose increased use of single-use technologies in biopharmaceutical manufacturing to achieve operational excellence without compromising product quality. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660545/Single-Use-PS18_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660545null XML http://pharmtech.findpharma.com/pharmtech/Analytics/Integrated-Microfluidic-LC-MS/ArticleStandard/Article/detail/660538?ref=25 The authors describe a new microfluidic-based workflow that integrates and automates glycan cleaveage, purification, and chromatographic separation onto a microfluidic liquid chromatography–mass spectrometry chip for MS detection. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660538null XML http://pharmtech.findpharma.com/pharmtech/Editor%27s+comment/Lyo-controversies/ArticleStandard/Article/detail/658088?ref=25 Last year, a member of the PTE editorial team attended the 2nd Annual Lyophilisation Conference in London (UK). 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658088null XML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Nanotechnology-A-lifeline-for-drying-pharma-pipeli/ArticleStandard/Article/detail/658089?ref=25 Pharmaceutical Technology Europe spoke with experts about the developments that have shaped the nanotechnology industry today and the benefits that this technology has to offer the pharmaceutical industry, which remain largely untapped. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658089/page30_thumbnail.jpg http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658089null XML http://pharmtech.findpharma.com/pharmtech/Analytics/Gamma-Irradiation-in-the-Pharmaceutical-Manufactur/ArticleStandard/Article/detail/660542?ref=25 The author reviews the benefits, challenges, and considerations to be made when selecting a gamma-irradiation sterilization method. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/112010/660542null XML http://pharmtech.findpharma.com/pharmtech/Whitepapers/Principals-of-Viral-Clearance-Study-Design-and-Per/ArticleStandard/Article/detail/659276?ref=25 Viral clearance studies are one of the three main contributors toward achieving assurance that an acceptable level of viral safety has been achieved for a product. Manufacturers need to justify the level of clearance achieved for each individual virus tested to the regulatory authorities. This paper outlines several key elements that need to be considered during the design and performance of these studies. 2010-03-01T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/102010/659276null REMOTE http://pharmtech.findpharma.com/pharmtech/Lilly-Merck-and-Pfizer-join-forces-to-fight-cancer/ArticleStandard/Article/detail/658488?ref=25 Eli Lilly, Merck Sharp & Dohme and Pfizer have joined together to form the Asian Cancer Research Group (ACRG), a not-for-profit company aimed at accelerating research and improving treatment for patients affected with the most commonly diagnosed cancers in Asia. 2010-02-26T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658488null HTML http://pharmtech.findpharma.com/pharmtech/Compliance-Accela-Form---Principals-of-Viral-Clear/ArticleStandard/Article/detail/659168?ref=25 Compliance Accela Form - Principals of Viral Clearance Study Design and Performance 2010-02-26T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/659168null HTML http://pharmtech.findpharma.com/pharmtech/News/Genentech-in-drug-discovery-agreement/ArticleStandard/Article/detail/658338?ref=25 The University of California, San Francisco (CA, USA; UCSF) has signed an agreement with Genentech with the aim of discovering and developing drug candidates for neurodegenerative diseases. 2010-02-26T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658338null HTML http://pharmtech.findpharma.com/pharmtech/News/Positive-outlook-for-UK-biotech-jobs/ArticleStandard/Article/detail/658339?ref=25 A significant increase in the recruitment of contract staff is expected during the next 12 months in the UK biotechnology sector, according to a survey conducted by SRG, which provides personnel to various science-based sectors. 2010-02-26T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658339null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Lilly-Merck-and-Pfizer-Join-Forces-to-Fight-Cancer/ArticleStandard/Article/detail/658545?ref=25 Eli Lilly, Merck Sharp & Dohme, and Pfizer form the Asian Cancer Research Group, a nonprofit aimed at accelerating research and improving treatment for patients affected with the most commonly diagnosed cancers in Asia. 2010-02-25T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658545null HTML http://pharmtech.findpharma.com/pharmtech/Regulation/Regulatory-Roundup-FDA-Issues-Data-On-Drug-Induced/ArticleStandard/Article/detail/658383?ref=25 FDA issues data on drug-induced liver injuries and serious skin reactions; IPEC Federation Week starts in France. 2010-02-25T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658383null HTML http://pharmtech.findpharma.com/pharmtech/News/Drug-Diverter-Sentenced-to-70-Months-in-Prison/ArticleStandard/Article/detail/658392?ref=25 Arnesto Segredo of Miami, Florida, was sentenced to 70 months in prison for conspiring to divert prescription drugs. 2010-02-25T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658392null HTML http://pharmtech.findpharma.com/pharmtech/Analytics/Week-Of-Feb-22-2010-Company-And-People-Notes-Merck/ArticleStandard/Article/detail/658385?ref=25 Merck To Eliminate 15,000 jobs; Tauzin Stepping Down At PhRMA; And More. 2010-02-25T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658385null HTML http://pharmtech.findpharma.com/pharmtech/Manufacturing/Positive-Outlook-for-UK-Biotech-Jobs/ArticleStandard/Article/detail/658390?ref=25 A significant increase in the recruitment of contract staff is expected during the next 12 months in the UK biotechnology sector, according to a survey conducted by SRG. 2010-02-25T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658390null HTML http://pharmtech.findpharma.com/pharmtech/Case+Study/TIBCO-Spotfire-provides-Dana-Farber-Cancer-Institu/ArticleStandard/Article/detail/658487?ref=25 Using Cao and Spotfire software, Dana-Farber's CVC developed a first-of-its-kind analysis approach to rapidly extract complex data specifically for cancer vaccines from the major clinical trial repository. 2010-02-23T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658487null PDF http://pharmtech.findpharma.com/pharmtech/Case+Study/Quality-control-of-liquids-in-the-21st-century/ArticleStandard/Article/detail/658150?ref=25 Liquids are used in a wide variety of industries, either during manufacture or as end-products in themselves. Whatever the end product, quality control of liquids is crucial to many industries. 2010-02-22T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658150null PDF http://pharmtech.findpharma.com/pharmtech/Copley-Revised-Accela-Form---Assessing-dry-powder-/ArticleStandard/Article/detail/658175?ref=25 Copley Revised Accela Form - Assessing dry powder inhalers 2010-02-22T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/092010/658175null HTML http://pharmtech.findpharma.com/pharmtech/Transparency-Paradigm-selecting-a-CRO-for-the-Endo/ArticleStandard/Article/detail/657939?ref=25 Transparency Paradigm: selecting a CRO for the Endocrine Program - Synomics Whitepaper 2010-02-19T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/657939null PDF http://pharmtech.findpharma.com/pharmtech/Waters-Accela-Form---Easy-Method-Transfer-from-HPL/ArticleStandard/Article/detail/658040?ref=25 Waters Accela Form - Easy Method Transfer from HPLC to UPLC 2010-02-19T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658040null HTML http://pharmtech.findpharma.com/pharmtech/Synomics-Accela-Form---Transparency-Paradigm-selec/ArticleStandard/Article/detail/657941?ref=25 Synomics Accela Form - Transparency Paradigm: selecting a CRO for the Endocrine Program 2010-02-19T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/657941null HTML http://pharmtech.findpharma.com/pharmtech/Method-Transfer-of-Loratadine-from-HPLC-to-UPLC-us/ArticleStandard/Article/detail/658037?ref=25 Method Transfer of Loratadine from HPLC to UPLC using the ACQUITY UPLC H-Class System - Waters Whitepaper 2010-02-19T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/658037null PDF http://pharmtech.findpharma.com/pharmtech/EMA-and-Swissmedic-to-share-H1N1-medicines-informa/ArticleStandard/Article/detail/657342?ref=25 The European Medicines Agency (EMA) and the Swiss Agency for Therapeutic Products, Swissmedic, have agreed to exchange information about the authorization and safety of H1N1 pandemic medicines. 2010-02-19T05:00:00Z http://pharmtech.findpharma.com/pharmtech/data/articlestandard/pharmtech/082010/657342null HTML